Clonal selection and hematopoietic phylogeny of TILs
Metastasis occurs when the most aggressive tumor cells disseminate and grow in other organs. The immune system is our major defense against cancer, as
Our interest in diverse aspects of myeloid biology in tumors never ends. From (dys)regulation of immune circadian rhythms in the tumor microenvironment to the understanding of lipid metabolism in tumor-associated macrophages, our projects aim to explore basic immunobiology mechanisms and discover novel modulatory functions of myeloid cells to treat cancer.
Metastasis occurs when the most aggressive tumor cells disseminate and grow in other organs. The immune system is our major defense against cancer, as
Immune checkpoint blockade (ICB) has revolutionized cancer care yet is ineffective in most patients. Predicting which patients will respond to ICB and how to
Myeloid cells are the most abundant leukocyte population in solid tumors. In contrast to the heterogeneity found in tumoral macrophages (tM𝜑s), the diversity of
Cancer can progress rapidly and every minute lost in ineffective treatment increases the likelihood that the patient will die. Therefore, identifying patients most likely
Circadian rhythms (CRs) are the biological response to the periodic rotations of the Earth, and allow
fundamental adaptations of organisms to a changing environment.